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One of the biggest challenges is predicting how a potential treatment will behave in the human body. Organ-on-chip technology offers a promising way forward, using miniature models of human tissues and organs to make drug testing more predictive and relevant to human biology.",[80],{"type":55,"attrs":81},{"color":15},{"type":29,"attrs":83},{"textAlign":14},{"type":29,"attrs":85,"content":86},{"textAlign":14},[87,92,102],{"text":88,"type":52,"marks":89},"With support from Twente Board, two new projects, GALLOP and LIPOSMART, will advance this technology through the ",[90],{"type":55,"attrs":91},{"color":15},{"text":93,"type":52,"marks":94},"Bio\u002FMicroSystems Centre (B\u002FMSC)",[95,100],{"type":96,"attrs":97},"link",{"href":98,"uuid":14,"anchor":14,"target":14,"linktype":99},"https:\u002F\u002Fbiomicrosystemscentre.nl\u002F","url",{"type":55,"attrs":101},{"color":15},{"text":103,"type":52,"marks":104},", a Joint Innovation Centre established by TNO and the University of Twente.",[105],{"type":55,"attrs":106},{"color":15},{"type":29,"attrs":108},{"textAlign":14},{"type":29,"attrs":110,"content":111},{"textAlign":14},[112],{"text":113,"type":52,"marks":114},"By combining expertise in microtechnology, materials science and life sciences with industrial collaboration, these projects aim to bridge the gap between laboratory research and practical applications in pharmaceutical development.",[115],{"type":55,"attrs":116},{"color":15},{"type":29,"attrs":118},{"textAlign":14},{"type":120,"attrs":121,"content":123},"heading",{"level":122,"textAlign":14},5,[124],{"text":125,"type":52,"marks":126},"Bringing greater precision to organ-on-chip technology",[127],{"type":55,"attrs":128},{"color":15},{"type":29,"attrs":130,"content":131},{"textAlign":14},[132],{"text":133,"type":52,"marks":134},"Organ-on-chip systems recreate specific functions of human organs on a miniature scale. By providing controlled environments in which human cells and tissues can grow, they enable researchers to study biological processes and investigate how potential medicines interact with the body.",[135],{"type":55,"attrs":136},{"color":15},{"type":29,"attrs":138},{"textAlign":14},{"type":29,"attrs":140,"content":141},{"textAlign":14},[142],{"text":143,"type":52,"marks":144},"However, making these systems suitable for widespread industrial use requires more than biological accuracy. Reliable measurements, stable materials and scalable production methods are equally important.",[145],{"type":55,"attrs":146},{"color":15},{"type":29,"attrs":148},{"textAlign":14},{"type":29,"attrs":150,"content":151},{"textAlign":14},[152],{"text":153,"type":52,"marks":154},"The two new projects address these challenges from different perspectives.",[155],{"type":55,"attrs":156},{"color":15},[],{"_uid":159,"image":160,"title":15,"anchor":15,"titleTag":66,"component":67,"titleColor":35,"aspectRatio":165,"description":166,"titleBorder":31,"componentWidth":37,"componentJustify":39,"contentSpacingPaddingX":40,"contentSpacingPaddingY":41},"30cf1f1d-e61a-4008-b091-4a4c3c143002",{"id":161,"alt":15,"name":15,"focus":15,"title":15,"source":15,"filename":162,"copyright":15,"fieldtype":16,"meta_data":163,"is_external_url":31},238370459934940,"https:\u002F\u002Fa.storyblok.com\u002Ff\u002F289273820865604\u002F1000x667\u002F909def3f04\u002F_vbw-1225-4124_small.jpg",{"size":164},"1000x667","2:1","Transparent wellplate",{"_uid":168,"text":169,"title":15,"anchor":15,"author":15,"buttons":386,"caption":15,"endDate":15,"hideTime":31,"titleTag":32,"component":33,"startDate":15,"textAlign":34,"titleColor":35,"titleBorder":31,"captionColor":36,"componentWidth":37,"buttonsDirection":38,"componentJustify":39,"contentSpacingPaddingX":40,"contentSpacingPaddingY":41},"9d9921ca-aa19-4afa-bbe3-8940175b9583",{"type":26,"attrs":170,"content":171},{"backgroundColor":14},[172,180,188,196,204,206,214,216,224,226,234,242,244,252,254,262,264,272,274,282,284,292,300,302,323,325,333,340,348,350,358,360,368,370],{"type":120,"attrs":173,"content":174},{"level":122,"textAlign":14},[175],{"text":176,"type":52,"marks":177},"GALLOP: Automating measurements for deeper biological insights",[178],{"type":55,"attrs":179},{"color":15},{"type":29,"attrs":181,"content":182},{"textAlign":14},[183],{"text":184,"type":52,"marks":185},"Understanding how living tissues respond to medicines requires precise and consistent measurements. Today, many sampling and analysis steps in organ-on-chip experiments are still performed manually, limiting how frequently researchers can collect data and potentially introducing variability. GALLOP aims to change this.",[186],{"type":55,"attrs":187},{"color":15},{"type":29,"attrs":189,"content":190},{"textAlign":14},[191],{"text":192,"type":52,"marks":193}," ",[194],{"type":55,"attrs":195},{"color":15},{"type":29,"attrs":197,"content":198},{"textAlign":14},[199],{"text":200,"type":52,"marks":201},"Together with Demcon life sciences & health, B\u002FMSC is developing technology to automate measurements and sample collection within microphysiological systems.",[202],{"type":55,"attrs":203},{"color":15},{"type":29,"attrs":205},{"textAlign":14},{"type":29,"attrs":207,"content":208},{"textAlign":14},[209],{"text":210,"type":52,"marks":211},"By integrating these processes at the microscale, researchers aim to collect more frequent and accurate measurements without disturbing the developing tissues.",[212],{"type":55,"attrs":213},{"color":15},{"type":29,"attrs":215},{"textAlign":14},{"type":29,"attrs":217,"content":218},{"textAlign":14},[219],{"text":220,"type":52,"marks":221},"The project will demonstrate a prototype of an integrated miniature measurement and analysis system, laying the groundwork for more scalable and automated monitoring of biological processes.",[222],{"type":55,"attrs":223},{"color":15},{"type":29,"attrs":225},{"textAlign":14},{"type":120,"attrs":227,"content":228},{"level":122,"textAlign":14},[229],{"text":230,"type":52,"marks":231},"LIPOSMART: Smarter materials for more reliable drug testing",[232],{"type":55,"attrs":233},{"color":15},{"type":29,"attrs":235,"content":236},{"textAlign":14},[237],{"text":238,"type":52,"marks":239},"The materials used in organ-on-chip systems can directly influence the quality of experimental results. Certain drug compounds can bind to conventional plastic surfaces, while miniature three-dimensional tissue models can be difficult to keep in position.",[240],{"type":55,"attrs":241},{"color":15},{"type":29,"attrs":243},{"textAlign":14},{"type":29,"attrs":245,"content":246},{"textAlign":14},[247],{"text":248,"type":52,"marks":249},"LIPOSMART addresses these challenges by developing advanced coatings and micro-laboratory plates designed to create a more stable environment for drug testing.",[250],{"type":55,"attrs":251},{"color":15},{"type":29,"attrs":253},{"textAlign":14},{"type":29,"attrs":255,"content":256},{"textAlign":14},[257],{"text":258,"type":52,"marks":259},"The project brings together B\u002FMSC, Lipocoat, Bondus and Swiss partner InSphero to develop technologies that minimise unwanted interactions between drugs, cells and materials.",[260],{"type":55,"attrs":261},{"color":15},{"type":29,"attrs":263},{"textAlign":14},{"type":29,"attrs":265,"content":266},{"textAlign":14},[267],{"text":268,"type":52,"marks":269},"The goal is to deliver a validated prototype, tested using a liver model, while exploring opportunities for scalable manufacturing and future commercialisation.",[270],{"type":55,"attrs":271},{"color":15},{"type":29,"attrs":273},{"textAlign":14},{"type":29,"attrs":275,"content":276},{"textAlign":14},[277],{"text":278,"type":52,"marks":279},"By involving industrial partners from the outset, the project connects technological development with the practical requirements of pharmaceutical research.",[280],{"type":55,"attrs":281},{"color":15},{"type":29,"attrs":283},{"textAlign":14},{"type":120,"attrs":285,"content":286},{"level":122,"textAlign":14},[287],{"text":288,"type":52,"marks":289},"From research to real-world impact",[290],{"type":55,"attrs":291},{"color":15},{"type":29,"attrs":293,"content":294},{"textAlign":14},[295],{"text":296,"type":52,"marks":297},"Both projects reflect a broader ambition: making advanced organ-on-chip technology more reliable, accessible and suitable for industrial adoption.",[298],{"type":55,"attrs":299},{"color":15},{"type":29,"attrs":301},{"textAlign":14},{"type":29,"attrs":303,"content":304},{"textAlign":14},[305,310,318],{"text":306,"type":52,"marks":307},"At TNO at Holst Centre, ",[308],{"type":55,"attrs":309},{"color":15},{"text":311,"type":52,"marks":312},"researchers are developing scalable organ-on-chip platforms",[313,316],{"type":96,"attrs":314},{"href":315,"uuid":14,"anchor":14,"target":14,"linktype":99},"https:\u002F\u002Fwww.tno.nl\u002Fen\u002Fhealthy\u002Fefficient-drug-development\u002Fvitro-platforms\u002Forgan-chip\u002F",{"type":55,"attrs":317},{"color":15},{"text":319,"type":52,"marks":320}," that combine microfluidics, electronics and advanced manufacturing technologies. These innovations build on expertise in integrating complex functionalities into standardised, cost-effective laboratory formats.",[321],{"type":55,"attrs":322},{"color":15},{"type":29,"attrs":324},{"textAlign":14},{"type":29,"attrs":326,"content":327},{"textAlign":14},[328],{"text":329,"type":52,"marks":330},"Through B\u002FMSC, this expertise is connected with the University of Twente's research capabilities and the knowledge of industrial partners, creating new opportunities to translate advanced technology into practical solutions.",[331],{"type":55,"attrs":332},{"color":15},{"type":29,"attrs":334,"content":335},{"textAlign":14},[336],{"text":192,"type":52,"marks":337},[338],{"type":55,"attrs":339},{"color":15},{"type":29,"attrs":341,"content":342},{"textAlign":14},[343],{"text":344,"type":52,"marks":345},"GALLOP and LIPOSMART also contribute to strengthening Twente's MedTech ecosystem, bringing together research organisations and businesses to accelerate innovation and support future economic growth.",[346],{"type":55,"attrs":347},{"color":15},{"type":29,"attrs":349},{"textAlign":14},{"type":29,"attrs":351,"content":352},{"textAlign":14},[353],{"text":354,"type":52,"marks":355},"The long-term opportunity is clear: more predictive drug testing, reduced reliance on animal testing and faster development of medicines.",[356],{"type":55,"attrs":357},{"color":15},{"type":29,"attrs":359},{"textAlign":14},{"type":29,"attrs":361,"content":362},{"textAlign":14},[363],{"text":364,"type":52,"marks":365},"By addressing the technical challenges that stand between research and industrial application, these collaborations are helping build the foundations for the next generation of pharmaceutical testing technologies.",[366],{"type":55,"attrs":367},{"color":15},{"type":29,"attrs":369},{"textAlign":14},{"type":29,"attrs":371,"content":372},{"textAlign":14},[373,378],{"text":374,"type":52,"marks":375},"Explore our organ-on-chip technologies by discovering ",[376],{"type":55,"attrs":377},{"color":15},{"text":379,"type":52,"marks":380},"how TNO at Holst Centre is advancing organ-on-chip platforms to support the future of drug development.",[381,384],{"type":96,"attrs":382},{"href":383,"uuid":14,"anchor":14,"target":14,"linktype":99},"https:\u002F\u002Ftwenteboard-nl.translate.goog\u002Fnl\u002Fartikelen\u002F5698\u002Ftwente-versterkt-medtech-ecosysteem-met-nieuwe-innovaties-voor-geneesmiddelontwikkeling\u002F?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en",{"type":55,"attrs":385},{"color":15},[],"contain","white","section","mx-0","my-0","page-content","New MedTech projects advance organ-on-chip drug testing",[],[396],"Medtech","Organ-on-chip technology, MedTech innovation, drug development, GALLOP, LIPOSMART",{"id":15,"url":15,"linktype":399,"fieldtype":400,"cached_url":15},"story","multilink",{"id":63,"alt":15,"name":15,"focus":15,"title":15,"source":15,"filename":64,"copyright":15,"fieldtype":16,"meta_data":402,"is_external_url":31},{"size":164},"Discover how GALLOP and LIPOSMART are advancing organ-on-chip technology through TNO, the University of Twente and industry collaboration.","2200-01-01 00:00","2026-11-05 00:00",{"id":15,"url":15,"linktype":399,"fieldtype":400,"cached_url":15},"two-new-medtech-projects-advance-more-reliable-drug-development","en\u002Finsights\u002Ftwo-new-medtech-projects-advance-more-reliable-drug-development",-170,[],124781506869136,"6bd939e2-e075-45bd-8eef-e5375d5c37cc","2026-11-05T13:40:43.086Z","default",[],[],1793886407383]