As technology advances, implantable medical devices are emerging as a game-changer in treating chronic diseases. These next-generation devices seamlessly integrate sensors and actuators, connecting with external wearables to create closed-loop solutions. Geert Langereis, Principal Member of Technical Staff at Holst Centre, reflects on the developments in this field.
“We don’t just develop devices; we create complete therapeutic solutions,” says Geert Langereis, like an artificial organ or a bioelectronic medicine. Holst Centre specializes in designing implantable medical devices that are smaller, more flexible, and energy efficient. The research spans material science, bioelectronics, and nanotechnology, allowing the specialized teams to develop cutting-edge neural interfaces and implantable sensors.
A key aspect of Holst Centre’s approach is closed-loop health systems, where implants and wearables work together for continuous monitoring and adaptive treatments. “By integrating sensors with AI-driven processing, we can personalize therapies and improve patient outcomes,” Langereis explains. “Only adaptive targeted systems can restore the quality of life and prevent progression of diseases, and the development of secondary diseases”
The advancements in bioelectronics
One of Holst Centre’s most significant achievements in 2023 was the development of localized vagus nerve stimulation. Unlike traditional vagus nerve stimulation, which affects the entire nerve and can cause side effects, Holst Centre’s innovation uses a precision silicon chip to apply targeted electrical stimulation via a cuff around the nerve.
“This technique could revolutionize treatments for conditions like high blood pressure, inflammation, and chronic pain,” says Langereis. The breakthrough paves the way for safer, more effective neuromodulation therapies with fewer side effects.
Another milestone is the speckle-based sensing method, which uses laser light to measure vital signs such as heart rate and breathing rate, even from a distance. This innovation has attracted industry interest, particularly in automotive health monitoring applications.
Societal impact:
This part of the health program focuses on extending therapies outside the hospital, resulting in concepts for peripheral-nerve-based bioelectronic medicine (BEM) and even artificial organs. These innovations have the potential to revolutionize healthcare by offering precise, adaptive treatments for a range of conditions, from neurological disorders to metabolic diseases.
As implantable technology advances, its acceptance in mainstream healthcare is growing. “We expect to see implantables used for less critical conditions in the near future, making them more accessible to a wider population,” says Langereis. “What if you can switch your treatment on and off, unlike hormone-based treatment? What if a firmware upgrade of your implant can bring the newest insights in healthcare to you bioelectronic medicine?”
Bioelectronic medicine
Looking ahead, Holst Centre aims to establish itself as a competence center for artificial organs and bioelectronic medicine. The vision is to shift the medical landscape towards minimally invasive, AI-driven implants that seamlessly integrate with the human body.
“We foresee a future where bioelectronic medicine addresses pain and inflammation-related conditions, such as rheumatoid arthritis,” Langereis explains. “Holst Centre is poised to lead this transition, creating solutions that transform lives.”
From smart neuromodulators to laser-based vital sign monitoring, Holst Centre is shaping a future where implantable technology isn’t just about treatment, it’s about enhancing quality of life.