Developing disease models that more closely mimic human physiology can lead to breakthroughs in medical treatment and accelerated drug development. In addition to being far more precise than animal models, microphysiological systems like Organ-on-Chip (OoC) are also more ethical, faster, and more manageable. Holst Centre is advancing OoC technologies and applications in a variety of ways, to help the medical community adopt innovative technologies that lead to faster drug development and better healthcare.
OoC from Imec at Holst Centre
At imec at Holst Centre, advanced sensing technologies are developed to enable precise, real-time monitoring within Organ-on-Chip systems. By integrating real-time sensing, imec moves OoC from static endpoint snaphots to continuous, data rich biological platforms. Building on imec’s strengths in nanoelectronics and sensor integration, these solutions enable robust data generation under complex biochemical conditions, feeding advanced analytics and AI. This ultimately contributes to improved predictability in personalised drug development and facilitates the adoption of OoC technologies in both research and industry applications.
OoC from TNO at Holst Centre
TNO at Holst Centre has developed adaptive, scalable OoC technology implemented in standardised and cost-effective well plates. Combining this technology with TNO’s extensive biological expertise has led to translational, preclinical modelling platforms for a variety of single and multi-organ applications, including liver and intestine. The preclinical models developed at Holst Centre are now ready for industry application through the Bio/MicroSystems Centre (B/MSC), a Joint Innovation Centre created by TNO and University of Twente. Those interested in shared research using OoC and other bio/microsystem technologies are encouraged to get in touch with the B/MSC.
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